{"id":110026,"date":"2026-07-22T15:53:00","date_gmt":"2026-07-22T13:53:00","guid":{"rendered":"https:\/\/rd-biotech.tetedecom.pro\/?page_id=110026"},"modified":"2026-07-27T15:53:46","modified_gmt":"2026-07-27T13:53:46","slug":"multi-system-approach","status":"publish","type":"page","link":"https:\/\/rd-biotech.tetedecom.pro\/en\/recombinant-protein-expression\/multi-system-approach\/","title":{"rendered":"Multi-system approach"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row row_height_percent=&#8221;40&#8243; back_image=&#8221;109703&#8243; back_repeat=&#8221;no-repeat&#8221; back_position=&#8221;center center&#8221; overlay_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;70&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;198253&#8243; row_height_pixel=&#8221;400&#8243; overlay_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;1&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;484880&#8243;][uncode_breadcrumbs][vc_empty_space empty_h=&#8221;2&#8243;][vc_custom_heading auto_text=&#8221;yes&#8221; text_size=&#8221;fontsize-155944&#8243; text_weight=&#8221;200&#8243; text_space=&#8221;fontspace-781688&#8243; uncode_shortcode_id=&#8221;497824&#8243;][\/vc_custom_heading][vc_empty_space empty_h=&#8221;2&#8243;][vc_custom_heading text_size=&#8221;h5&#8243; text_weight=&#8221;200&#8243; css_animation=&#8221;alpha-anim&#8221; animation_speed=&#8221;2000&#8243; uncode_shortcode_id=&#8221;137460&#8243;]Entrust the expression of your recombinant proteins to our expert platform, which supports a comprehensive range of expression systems: <em data-start=\"367\" data-end=\"385\">Escherichia coli<\/em>, mammalian CHO and HEK cells, yeast and cell-free technologies.[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;234044&#8243; row_height_pixel=&#8221;0&#8243; overlay_color_type=&#8221;uncode-palette&#8221; back_color_type=&#8221;uncode-palette&#8221; el_id=&#8221;protein-expression-in-escherichia-coli&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_custom_heading text_color=&#8221;color-109923&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;400&#8243; uncode_shortcode_id=&#8221;639257&#8243; text_color_type=&#8221;uncode-palette&#8221; el_id=&#8221;avantages-systeme-hybridomes&#8221;]Protein expression in\u00a0<em data-start=\"902\" data-end=\"920\">Escherichia coli<\/em>[\/vc_custom_heading][vc_column_text text_color=&#8221;color-109923&#8243; uncode_shortcode_id=&#8221;129161&#8243; text_color_type=&#8221;uncode-palette&#8221;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"504\" data-end=\"691\">Fast, cost-effective <strong>bioproduction of recombinant proteins in <em data-start=\"566\" data-end=\"575\">E. coli<\/em><\/strong>. This system is ideal for non-glycosylated proteins, antigens, enzymes and antibody fragments such as scFv and Fab.<\/p>\n<p data-start=\"693\" data-end=\"788\">From gene design to purification, we optimize expression and solubility to achieve high yields.<\/p>\n<p>[\/vc_column_text][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Anticorps bisp\u00e9cifiques&#8221; tab_id=&#8221;1772808992395-2-3177753499153529217796966737951784808404053&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;214884&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;767741&#8243;]<span style=\"font-weight: 400;\">Notre savoir-faire couvre \u00e9galement la<strong> production d\u2019anticorps bisp\u00e9cifiques<\/strong>, capables de reconna\u00eetre et de se lier simultan\u00e9ment \u00e0 deux antig\u00e8nes ou \u00e9pitopes distincts. Ces mol\u00e9cules sophistiqu\u00e9es repr\u00e9sentent des <strong>outils de choix en th\u00e9rapie<\/strong>, permettant des strat\u00e9gies de ciblage innovantes et plus pr\u00e9cises pour le traitement de pathologies.<\/span>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;110988&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;206921&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Anticorps afucosyl\u00e9s&#8221; tab_id=&#8221;1757666499-2-86177753499153568717796966737951784808404053&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;957560&#8243;]<span style=\"font-weight: 400;\">Nous\u00a0 proposons un service de <strong>production d\u2019anticorps afucosyl\u00e9s<\/strong>, caract\u00e9ris\u00e9s par une activit\u00e9 ADCC renforc\u00e9e. D\u00e9pourvus de r\u00e9sidus de fucose au niveau de leur r\u00e9gion Fc, ces <strong>anticorps<\/strong> pr\u00e9sentent une <strong>cytotoxicit\u00e9 cellulaire am\u00e9lior\u00e9e<\/strong>. Cette optimisation favorise une meilleure r\u00e9ponse immunitaire, am\u00e9liore l\u2019efficacit\u00e9 th\u00e9rapeutique et peut contribuer \u00e0 r\u00e9duire les effets ind\u00e9sirables.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;110989&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;190569&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Fragments d\u2019anticorps \/ VHH&#8221; tab_id=&#8221;1777535231154-3-640517796966737951784808404053&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;599018&#8243;]<span style=\"font-weight: 400;\">Les <strong>fragments d\u2019anticorps<\/strong> (ScFv, Fab, Fab\u20192) et les VHH caract\u00e9ris\u00e9s par leur petite taille pr\u00e9sentent plusieurs int\u00e9r\u00eats strat\u00e9giques, scientifiques et industriels. L\u2019acc\u00e8s \u00e0 des \u00e9pitopes inaccessibles, une meilleure p\u00e9n\u00e9tration tissulaire, l\u2019\u00e9limination des fonctions effectrices immunitaires du Fc et bien plus encore font de ces mol\u00e9cules des outils extr\u00eamement polyvalents.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400; text-align: left;\" aria-level=\"1\"><b>Expertise multi-isotypes :<\/b><span style=\"font-weight: 400;\"> Purification d&#8217;IgG, IgM, IgA, IgY, etc.<\/span><\/li>\n<li style=\"font-weight: 400; text-align: left;\" aria-level=\"1\"><b>Livraison pr\u00eate \u00e0 l&#8217;emploi :<\/b><span style=\"font-weight: 400;\"> Vos <strong>anticorps<\/strong> sont \u00e9quilibr\u00e9s dans le tampon de votre choix et livr\u00e9s avec un rapport de purification complet.<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;110989&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;998725&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Anticorps Humanis\u00e9s&#8221; tab_id=&#8221;1777882602171-4-1017796966737951784808404053&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;202276&#8243;]<span style=\"font-weight: 400;\">Les<strong> anticorps humanis\u00e9s<\/strong> repr\u00e9sentent aujourd\u2019hui la majorit\u00e9 des anticorps th\u00e9rapeutiques approuv\u00e9s sur le march\u00e9.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">L\u2019<strong>humanisation d\u2019un anticorps<\/strong> parental est r\u00e9alis\u00e9e suivant une version modernis\u00e9e de \u201cCDR-grafting\u201d d\u00e9velopp\u00e9e par Winter\u00a0<\/span><i><span style=\"font-weight: 400;\">et al<\/span><\/i><span style=\"font-weight: 400;\">. (\u00ab Medical Research Council \u00bb \u2013 Cambridge \u2013 UK). Cette approche consiste \u00e0 ins\u00e9rer les r\u00e9gions CDR (Complementary Determining Regions) d\u2019un anticorps parental, g\u00e9n\u00e9ralement murin, dans une structure d\u2019<strong>anticorps humain<\/strong>. Cette strat\u00e9gie permet de <strong>conserver la sp\u00e9cificit\u00e9 et l\u2019affinit\u00e9 pour l\u2019antig\u00e8ne<\/strong> tout en <strong>r\u00e9duisant l\u2019immunog\u00e9nicit\u00e9<\/strong> chez l\u2019homme.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Apr\u00e8s cette \u00e9tape d\u2019humanisation, une optimisation des s\u00e9quences peut \u00eatre propos\u00e9e avec en option des analyses compl\u00e9mentaires par mod\u00e9lisation mol\u00e9culaire.\u00a0Les objectifs \u00e9tant :<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">d\u2019am\u00e9liorer la manufacturabilit\u00e9 en r\u00e9duisant l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">d\u2019augmenter l\u2019affinit\u00e9 et l\u2019activit\u00e9 biologique de l\u2019anticorps (IC50)<\/span><\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;110990&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;205403&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Prot\u00e9ines recombinantes et anticorps de fusion&#8221; tab_id=&#8221;1777883770378-5-417796966737951784808404053&#8243;][vc_row_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text uncode_shortcode_id=&#8221;105779&#8243;]<span style=\"font-weight: 400;\">RD-Biotech met \u00e9galement son expertise au service du d\u00e9veloppement et de la production de vos <a href=\"https:\/\/rd-biotech.tetedecom.pro\/en\/recombinant-protein-expression\/\"><strong>prot\u00e9ines recombinantes<\/strong><\/a> , avec la possibilit\u00e9 de les fusionner \u00e0 un domaine Fc afin d\u2019optimiser leurs performances selon les besoins sp\u00e9cifiques de votre projet.<\/span>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;166747&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_tabs tab_scrolling=&#8221;yes&#8221; uncode_shortcode_id=&#8221;605913&#8243; el_class=&#8221;tab-services mobile-tabs-to-dropdown&#8221;][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Recombinant expression in E. coli&#8221; tab_id=&#8221;1757666499-1-6177753499153529317796968759551784808404206&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;0&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;955701&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;0&#8243; border_color=&#8221;transparent&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;100505&#8243; el_class=&#8221;service-box&#8221; border_color_type=&#8221;uncode-palette&#8221; css=&#8221;.vc_custom_1784229043415{border-top-width: 0px !important;}&#8221;][vc_column_text uncode_shortcode_id=&#8221;108186&#8243;]<\/p>\n<p id=\"tw-target-text\" class=\"tw-data-text tw-text-large tw-ta\" dir=\"ltr\" style=\"text-align: left;\" tabindex=\"-1\" role=\"text\" data-placeholder=\"Traduction\" data-ved=\"2ahUKEwiTwtD-6eiVAxWOcvEDHU04IxoQ3ewLegQIDRAV\" aria-label=\"Texte traduit\u00a0: Recombinant protein production in *E. coli* remains the fastest and most cost-effective expression system for many applications.\"><span class=\"Y2IQFc\" lang=\"en\"><strong>Recombinant protein production<\/strong> in <em>E. coli<\/em> remains the fastest and most cost-effective expression system for many applications.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;91419&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;hg&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;805690&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Recognized expertise in bacteriology&#8221; tab_id=&#8221;1772808992395-2-3177753499153529217796968759551784808404206&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;214884&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;201161&#8243;]<\/p>\n<p id=\"tw-target-text\" class=\"tw-data-text tw-text-large tw-ta\" dir=\"ltr\" style=\"text-align: left;\" tabindex=\"-1\" role=\"text\" data-placeholder=\"Traduction\" data-ved=\"2ahUKEwiTwtD-6eiVAxWOcvEDHU04IxoQ3ewLegQIDRAV\" aria-label=\"Texte traduit\u00a0: Drawing on over 20 years of expertise in bacteriology, we optimize recombinant protein cloning and expression to maximize yields while ensuring soluble and functional proteins.\"><span class=\"Y2IQFc\" lang=\"en\">Drawing on over 25 years of <strong>expertise in bacteriology<\/strong>, we <strong>optimize recombinant protein<\/strong> <strong>cloning<\/strong> and expression to maximize yields while ensuring soluble and functional proteins.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;System applications and performance&#8221; tab_id=&#8221;1757666499-2-86177753499153568717796968759551784808404206&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;164856&#8243;]<\/p>\n<p id=\"tw-target-text\" class=\"tw-data-text tw-text-large tw-ta\" dir=\"ltr\" style=\"text-align: left;\" tabindex=\"-1\" role=\"text\" data-placeholder=\"Traduction\" data-ved=\"2ahUKEwiTwtD-6eiVAxWOcvEDHU04IxoQ3ewLegQIDRAV\" aria-label=\"Texte traduit\u00a0: Ideal for prokaryotic proteins, antigens, enzymes, or cytosolic domains, this system offers an excellent cost-to-yield ratio, with production levels reaching several hundred milligrams per batch.\"><span class=\"Y2IQFc\" lang=\"en\">Ideal for <strong>prokaryotic proteins<\/strong>, <strong>antigens<\/strong>, enzymes, or cytosolic domains, this system offers an excellent cost-to-yield ratio, with production levels reaching several hundred milligrams per batch.<\/span><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Control of solubilization and renaturation&#8221; tab_id=&#8221;1777535231154-3-640517796968759551784808404206&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;122085&#8243;]<\/p>\n<div class=\"qMYqUG_convSearchResultHighlightRoot\">\n<div class=\"\" data-turn-id-container=\"request-WEB:153050e8-0af2-4dbd-9b37-6cfd94df133b-1\" data-is-intersecting=\"true\">\n<section class=\"text-token-text-primary w-full focus:outline-none has-data-writing-block:pointer-events-none [&amp;:has([data-writing-block])&gt;*]:pointer-events-auto R6Vx5W_threadScrollVars scroll-mb-[calc(var(--scroll-root-safe-area-inset-bottom,0px)+var(--thread-response-height))] scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]\" dir=\"auto\" data-turn-id=\"request-WEB:153050e8-0af2-4dbd-9b37-6cfd94df133b-1\" data-turn-id-container=\"request-WEB:153050e8-0af2-4dbd-9b37-6cfd94df133b-1\" data-testid=\"conversation-turn-2\" data-scroll-anchor=\"false\" data-turn=\"assistant\">\n<div class=\"text-base my-auto mx-auto pb-10 [--thread-content-margin:var(--thread-content-margin-xs,calc(var(--spacing)*4))] @w-sm\/main:[--thread-content-margin:var(--thread-content-margin-sm,calc(var(--spacing)*6))] @w-lg\/main:[--thread-content-margin:var(--thread-content-margin-lg,calc(var(--spacing)*16))] px-(--thread-content-margin)\">\n<div class=\"[--thread-content-max-width:40rem] @w-lg\/main:[--thread-content-max-width:48rem] mx-auto max-w-(--thread-content-max-width) flex-1 group\/turn-messages focus-visible:outline-hidden relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex max-w-full flex-col gap-4 grow\">\n<div class=\"min-h-8 text-message relative flex w-full flex-col items-end gap-2 text-start break-words whitespace-normal outline-none keyboard-focused:focus-ring [.text-message+&amp;]:mt-1\" dir=\"auto\" tabindex=\"0\" data-message-author-role=\"assistant\" data-message-id=\"5e5bc510-2569-4d91-8152-c1cd8331542b\" data-message-model-slug=\"gpt-5-5\" data-turn-start-message=\"true\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden\">\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full dark markdown-new-styling\">\n<p id=\"tw-target-text\" class=\"tw-data-text tw-text-large tw-ta\" dir=\"ltr\" style=\"text-align: left;\" tabindex=\"-1\" role=\"text\" data-placeholder=\"Traduction\" data-ved=\"2ahUKEwiTwtD-6eiVAxWOcvEDHU04IxoQ3ewLegQIDRAV\" aria-label=\"Texte traduit\u00a0: We have mastered the critical steps of renaturation and solubilization\u2014including the removal of inclusion bodies\u2014to obtain proteins suited to your research or industrial applications.\"><span class=\"Y2IQFc\" lang=\"en\">We have mastered the critical steps of renaturation and solubilization\u2014including the removal of inclusion bodies\u2014to obtain proteins suited to your research or industrial applications.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"z-0 flex min-h-[46px] justify-start\" style=\"text-align: left;\"><\/div>\n<div class=\"mt-3 w-full empty:hidden\" style=\"text-align: left;\">\n<div class=\"text-center\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<div class=\"pointer-events-none -mt-px h-px translate-y-[calc(var(--scroll-root-safe-area-inset-bottom)-14*var(--spacing))]\" style=\"text-align: left;\" aria-hidden=\"true\"><\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tab][\/vc_tabs][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;70&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;593328&#8243; overlay_color_type=&#8221;uncode-palette&#8221; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;185208&#8243;][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Une expertise reconnue en bact\u00e9riologie&#8221; tab_id=&#8221;1772808992395-2-31777534991535292177969601836351784808404345&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;214884&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;642401&#8243;]<\/p>\n<p data-start=\"243\" data-end=\"461\">Gr\u00e2ce \u00e0 <strong>plus de 20 ans d\u2019expertise en bact\u00e9riologie<\/strong>, nous optimisons le <strong>clonage<\/strong> et l\u2019<strong>expression de prot\u00e9ines recombinantes<\/strong> afin de maximiser les rendements tout en garantissant des prot\u00e9ines solubles et fonctionnelles.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Applications et performances du syst\u00e8me&#8221; tab_id=&#8221;1757666499-2-861777534991535687177969601836331784808404345&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;2\/3&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;852425&#8243;]<\/p>\n<p data-start=\"513\" data-end=\"737\">Id\u00e9al pour les <strong>prot\u00e9ines procaryotes<\/strong>, les <strong>antig\u00e8nes<\/strong>, les <strong>enzymes<\/strong> ou les domaines cytosoliques, ce syst\u00e8me offre un excellent compromis <strong>co\u00fbt\/rendement<\/strong>, avec des productions pouvant atteindre <strong>plusieurs centaines de mg par lot<\/strong>.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_color=&#8221;color-xsdn&#8221; back_image=&#8221;89450&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;hg&#8221; border_color=&#8221;transparent&#8221; border_style=&#8221;solid&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243; uncode_shortcode_id=&#8221;191329&#8243; back_color_type=&#8221;uncode-palette&#8221; border_color_type=&#8221;uncode-palette&#8221; css=&#8221;.vc_custom_1777878827836{border-top-width: 1px !important;border-right-width: 1px !important;border-bottom-width: 1px !important;border-left-width: 1px !important;}&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Ma\u00eetrise de la solubilisation et de la renaturation&#8221; tab_id=&#8221;1777535231154-3-6405177969601836361784808404345&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;256557&#8243; el_class=&#8221;services-hover vc_custom_preserve_mobile&#8221;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;334868&#8243; el_class=&#8221;service-box&#8221;][vc_column_text uncode_shortcode_id=&#8221;140561&#8243;]<\/p>\n<p style=\"text-align: left;\">Nous ma\u00eetrisons les \u00e9tapes critiques de <strong>renaturation<\/strong>, de <strong>solubilisation<\/strong> ainsi que l\u2019<strong>\u00e9limination des corps d\u2019inclusion<\/strong> afin d\u2019obtenir des prot\u00e9ines exploitables pour vos applications de recherche ou industrielles.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_tab][vc_custom_heading heading_semantic=&#8221;h4&#8243; uncode_shortcode_id=&#8221;121469&#8243;]Why choose <em data-start=\"1589\" data-end=\"1598\">E. coli<\/em> with RD-Biotech?[\/vc_custom_heading][vc_column_text text_color=&#8221;color-109923&#8243; uncode_shortcode_id=&#8221;616346&#8243; text_color_type=&#8221;uncode-palette&#8221;]<\/p>\n<ul>\n<li data-section-id=\"h7hlut\" data-start=\"1617\" data-end=\"1687\"><strong data-start=\"1619\" data-end=\"1645\">Very short lead times:<\/strong> purified protein in less than three weeks<\/li>\n<li data-section-id=\"1aq14fg\" data-start=\"1688\" data-end=\"1771\"><strong data-start=\"1690\" data-end=\"1711\">Optimized yields:<\/strong> coordinated, customized optimization throughout the process<\/li>\n<li data-section-id=\"ylwxsi\" data-start=\"1772\" data-end=\"1884\"><strong data-start=\"1774\" data-end=\"1814\">Endotoxin-free recombinant proteins:<\/strong> suitable for recombinant protein vaccines and immunology applications<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;0&#8243; back_color=&#8221;accent&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;116396&#8243; back_color_type=&#8221;uncode-palette&#8221; el_id=&#8221;protein-expression-in-CHO-and-HEK-cells&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_custom_heading text_color=&#8221;color-xsdn&#8221; text_size=&#8221;h1&#8243; text_weight=&#8221;400&#8243; uncode_shortcode_id=&#8221;117378&#8243; text_color_type=&#8221;uncode-palette&#8221;]Protein expression in CHO and HEK cells[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; back_color=&#8221;accent&#8221; overlay_color=&#8221;accent&#8221; overlay_alpha=&#8221;100&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;377773&#8243; overlay_color_type=&#8221;uncode-palette&#8221; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;3&#8243; style=&#8221;dark&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;203198&#8243;][vc_column_text text_color=&#8221;color-xsdn&#8221; uncode_shortcode_id=&#8221;474643&#8243; text_color_type=&#8221;uncode-palette&#8221;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"1937\" data-end=\"2030\"><strong>Bioproduction of proteins<\/strong>, including r<strong>ecombinant antibodies in mammalian cells<\/strong> (<strong>CHO<\/strong> and <strong>HEK293<\/strong>) .<\/p>\n<p data-start=\"2032\" data-end=\"2285\">We support your project from <strong>sequence design<\/strong> through to production, providing the appropriate post-translational modifications, including glycosylation and correct protein folding, together with high productivity and straightforward industrial scale-up.<\/p>\n<p>[\/vc_column_text][vc_accordion label_border=&#8221;yes&#8221; content_border=&#8221;yes&#8221; gutter_simple=&#8221;0&#8243; uncode_shortcode_id=&#8221;121983&#8243; active_tab=&#8221;0&#8243;][vc_accordion_tab gutter_size=&#8221;2&#8243; column_padding=&#8221;2&#8243; title=&#8221;Learn more&#8221; tab_id=&#8221;1778852456-1-261784808404538&#8243;][vc_row_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; style=&#8221;dark&#8221; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;2\/3&#8243; uncode_shortcode_id=&#8221;460509&#8243;][vc_column_text text_color=&#8221;color-xsdn&#8221; uncode_shortcode_id=&#8221;142207&#8243; text_color_type=&#8221;uncode-palette&#8221;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"2303\" data-end=\"2551\">For <strong>therapeutic recombinant proteins<\/strong> and <strong>proteins requiring native post-translational modifications <\/strong>(such as glycosylation, phosphorylation and disulfide-bond formation) eukaryotic mammalian systems using <strong>CHO<\/strong> or <strong>HEK293 cells<\/strong> are the preferred choice.<\/p>\n<p data-start=\"2553\" data-end=\"2671\">RD-Biotech has extensive expertise in <strong>suspension cell lines<\/strong>, enabling rapid assessment through transient transfection.<\/p>\n<p data-start=\"2673\" data-end=\"2713\">The resulting<strong> recombinant proteins<\/strong> have:<\/p>\n<ul data-start=\"2715\" data-end=\"2788\">\n<li data-section-id=\"1mg4il\" data-start=\"2715\" data-end=\"2735\">A native structure<\/li>\n<li data-section-id=\"1wyt9c\" data-start=\"2736\" data-end=\"2765\">Optimal biological activity<\/li>\n<li data-section-id=\"3atr6l\" data-start=\"2766\" data-end=\"2788\">Low endotoxin levels<\/li>\n<\/ul>\n<p data-start=\"2790\" data-end=\"2904\">They are therefore ideally suited to <em>in vivo<\/em> studies, <strong>recombinant protein vaccines<\/strong> and biotherapeutic development.<\/p>\n<p data-section-id=\"md65md\" data-start=\"2906\" data-end=\"2922\"><strong>Key benefits<\/strong><\/p>\n<ul data-start=\"2924\" data-end=\"3122\">\n<li data-section-id=\"12ccbc6\" data-start=\"2924\" data-end=\"2993\">Accurate preservation of mammalian post-translational modifications<\/li>\n<li data-section-id=\"29wlfe\" data-start=\"2994\" data-end=\"3038\">Smooth scale-up from millilitres to litres<\/li>\n<li data-section-id=\"cyavc7\" data-start=\"3039\" data-end=\"3104\">Purified batches ranging from a few milligrams to several grams<\/li>\n<li data-section-id=\"17ncvor\" data-start=\"3105\" data-end=\"3122\">Fast production<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;89063&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243; uncode_shortcode_id=&#8221;202908&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_accordion_tab][\/vc_accordion][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;0&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;945595&#8243; back_color_type=&#8221;uncode-palette&#8221; el_id=&#8221;protein-expression-in-yeast&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_custom_heading text_color=&#8221;color-109923&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;400&#8243; uncode_shortcode_id=&#8221;895116&#8243; text_color_type=&#8221;uncode-palette&#8221;]Protein expression in yeast[\/vc_custom_heading][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;40&#8243; back_color=&#8221;color-xsdn&#8221; overlay_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;70&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;211105&#8243; row_height_pixel=&#8221;400&#8243; overlay_color_type=&#8221;uncode-palette&#8221; back_color_type=&#8221;uncode-palette&#8221; el_id=&#8221;Expression-de-votre-proteine-en-levure&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;284544&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;4&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;129206&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; radius=&#8221;hg&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/3&#8243; uncode_shortcode_id=&#8221;521107&#8243;][vc_column_text text_color=&#8221;color-109923&#8243; uncode_shortcode_id=&#8221;663076&#8243; text_color_type=&#8221;uncode-palette&#8221;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"3164\" data-end=\"3253\">A high-performance yeast system for the<strong> cost-effective production of eukaryotic proteins<\/strong>.<\/p>\n<p data-start=\"3255\" data-end=\"3458\">It provides excellent secretion capacity, <strong>eukaryotic post-translational modifications<\/strong> and high yields. It is an ideal, economical solution for proteins that are difficult to express in bacterial systems.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text uncode_shortcode_id=&#8221;462911&#8243;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"3460\" data-end=\"3661\">Yeast expression systems using <strong><em data-start=\"3491\" data-end=\"3508\">Pichia pastoris<\/em> or <\/strong><em data-start=\"3512\" data-end=\"3538\"><strong>Saccharomyces cerevisiae<\/strong><\/em> combine the rapid growth of bacteria with post-translational modifications similar to those produced by mammalian systems.<\/p>\n<p class=\"\" data-start=\"3663\" data-end=\"3834\">These systems are ideal for <strong>complex, secreted or glycosylated proteins<\/strong>. They enable direct secretion into the culture medium and provide inherently endotoxin-free quality.<\/p>\n<p data-start=\"3836\" data-end=\"4067\">We <strong>optimize sequences<\/strong> and induction conditions to achieve high yields of up to several hundred milligrams. These systems are particularly well suited to <strong>recombinant proteins intended for preclinical research<\/strong> or <strong>vaccine formulation<\/strong>.<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;2&#8243; bottom_padding=&#8221;4&#8243; back_color=&#8221;color-xsdn&#8221; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;882158&#8243; back_color_type=&#8221;uncode-palette&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_custom_heading heading_semantic=&#8221;h4&#8243; uncode_shortcode_id=&#8221;172897&#8243;]What are the benefits of <strong><em data-start=\"4098\" data-end=\"4115\">Pichia pastoris<\/em> and <em data-start=\"4120\" data-end=\"4146\">Saccharomyces cerevisiae<\/em> expression systems<\/strong>?[\/vc_custom_heading][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;5&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;935375&#8243; row_height_pixel=&#8221;200&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;0&#8243; expand_height=&#8221;yes&#8221; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;258661&#8243;][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-flask&#8221; icon_color=&#8221;color-193705&#8243; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;595617&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Efficient expression&#8221;]<em>High-level expression of recombinant proteins, including complex proteins.<\/em>[\/vc_icon][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-check&#8221; icon_color=&#8221;accent&#8221; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;410252&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Safe and reliable&#8221;]<em>Robust, well-characterized, non-pathogenic systems with GRAS status Generally Recognized as Safe.<\/em>[\/vc_icon][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-eur&#8221; icon_color=&#8221;accent&#8221; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;953319&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Cost-effective solution&#8221;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"4424\" data-end=\"4475\"><em>Lower production costs than mammalian cell systems.<\/em><\/p>\n<p>[\/vc_icon][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-dashboard&#8221; icon_color=&#8221;accent&#8221; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;149374&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Rapid growth and high-density cultures&#8221;]<em>Cost-effective large-scale production.<\/em>[\/vc_icon][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-code-fork&#8221; icon_color=&#8221;accent&#8221; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;129646&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Post-translational modifications&#8221;]<em>Performance of essential eukaryotic post-translational modifications, including glycosylation.<\/em>[\/vc_icon][vc_icon position=&#8221;left&#8221; space_reduced=&#8221;yes&#8221; icon=&#8221;fa fa-retweet&#8221; icon_color=&#8221;accent&#8221; heading_semantic=&#8221;div&#8221; text_size=&#8221;h5&#8243; uncode_shortcode_id=&#8221;153946&#8243; icon_color_type=&#8221;uncode-palette&#8221; title=&#8221;Versatility&#8221;]<em>Suitable for a wide variety of proteins, including enzymes, recombinant antibodies and therapeutic proteins.<\/em>[\/vc_icon][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;193891&#8243;][vc_single_image media=&#8221;102119&#8243; media_width_percent=&#8221;100&#8243; shape=&#8221;img-round&#8221; radius=&#8221;xl&#8221; uncode_shortcode_id=&#8221;675249&#8243;][vc_single_image media=&#8221;89122&#8243; media_width_percent=&#8221;100&#8243; shape=&#8221;img-round&#8221; radius=&#8221;xl&#8221; uncode_shortcode_id=&#8221;228974&#8243;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;3&#8243; bottom_padding=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;203059&#8243; back_color_type=&#8221;uncode-solid&#8221; back_color_solid=&#8221;#f0fbff&#8221; el_id=&#8221;protein-expression-using-cell-free-systems&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_custom_heading text_color=&#8221;color-109923&#8243; text_size=&#8221;h1&#8243; text_weight=&#8221;400&#8243; uncode_shortcode_id=&#8221;511993&#8243; text_color_type=&#8221;uncode-palette&#8221;]Protein expression using cell-free systems[\/vc_custom_heading][vc_column_text text_color=&#8221;color-109923&#8243; uncode_shortcode_id=&#8221;127320&#8243; text_color_type=&#8221;uncode-palette&#8221;]A cell-free expression system for the ultra-fast production within (only a few hours) of toxic, unstable or difficult-to-express proteins that cannot readily be produced in living systems.[\/vc_column_text][\/vc_column][\/vc_row][vc_row row_height_percent=&#8221;0&#8243; override_padding=&#8221;yes&#8221; h_padding=&#8221;2&#8243; top_padding=&#8221;2&#8243; bottom_padding=&#8221;4&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;3&#8243; column_width_percent=&#8221;100&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; content_parallax=&#8221;0&#8243; uncode_shortcode_id=&#8221;165799&#8243; back_color_type=&#8221;uncode-solid&#8221; back_color_solid=&#8221;#f0fbff&#8221;][vc_column column_width_use_pixel=&#8221;yes&#8221; position_horizontal=&#8221;left&#8221; position_vertical=&#8221;middle&#8221; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; align_mobile=&#8221;align_center_mobile&#8221; mobile_width=&#8221;0&#8243; width=&#8221;1\/1&#8243; uncode_shortcode_id=&#8221;932974&#8243;][vc_row_inner row_inner_height_percent=&#8221;0&#8243; overlay_alpha=&#8221;50&#8243; gutter_size=&#8221;4&#8243; shift_y=&#8221;0&#8243; z_index=&#8221;0&#8243; uncode_shortcode_id=&#8221;143795&#8243;][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; override_padding=&#8221;yes&#8221; column_padding=&#8221;0&#8243; expand_height=&#8221;yes&#8221; back_image=&#8221;99909&#8243; overlay_alpha=&#8221;50&#8243; radius=&#8221;xl&#8221; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;171512&#8243;][\/vc_column_inner][vc_column_inner column_width_percent=&#8221;100&#8243; gutter_size=&#8221;3&#8243; overlay_alpha=&#8221;50&#8243; shift_x=&#8221;0&#8243; shift_y=&#8221;0&#8243; shift_y_down=&#8221;0&#8243; z_index=&#8221;0&#8243; medium_width=&#8221;0&#8243; mobile_width=&#8221;0&#8243; width=&#8221;1\/2&#8243; uncode_shortcode_id=&#8221;193891&#8243;][vc_column_text uncode_shortcode_id=&#8221;138903&#8243;]<\/p>\n<p class=\"PDq2pG_selectionAnchorContainer\" data-start=\"5211\" data-end=\"5387\">The wheat germ extract (WGE\u2014cell-free system) is an alternative solution for toxic proteins, membrane proteins and other proteins that are difficult to express in living systems.<\/p>\n<p data-start=\"5389\" data-end=\"5543\">Its open environment provides improved protein folding and allows detergents, lipids or cofactors to be added directly. 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