GMP - Grade Plasmid Manufacturing Facility

In the production of lentiviral vectors used for cell therapies (including modified CAR-T, NK and iPSC cells) the quality of the plasmids used during transfection is a key factor.

High-quality plasmids with a very high proportion of supercoiled DNA and very low levels of endotoxins, residual genomic DNA and other impurities enable stable, coordinated expression of the gag/pol, rev, env and transfer plasmids.

Effective upstream control results in higher viral titers, improved reproducibility and reduced batch-to-batch variability.

For clinical and commercial applications, plasmid quality directly affects lentiviral-vector safety and process robustness. A well-controlled impurity profile reduces the risk of immune activation and residual contaminants while facilitating regulatory compliance.

Premium-grade plasmids also ensure consistent performance during critical stages—including transfection, production, clarification and purification—and support smooth scale-up from preclinical development to clinical and commercial batches.

Investing in high-quality plasmids strengthens the reliability of your lentiviral platform and secures your cell-therapy programs.

For mRNA-based applications, RD-Biotech supplies high-quality circular plasmids ready for linearization or plasmids already linearized according to customer specifications.

Linearized plasmids are the preferred templates for the in vitro transcription processes used to produce messenger RNA.

Our GMP batches are supplied with:

• Restriction profiles
• Sequence confirmation
• Evidence demonstrating the absence of residual genomic DNA contamination