Biomanufacturing
Discover our R&D, HQ and GMP grade plasmid bioproduction solutions, as well as our process development expertise tailored to the requirements of each project.
R&D grade plasmid bioproduction
A fast and flexible solution! From µg quantities to hundreds of mg, we tailor production to your specifications, supporting every stage of your development programmes.
HQ grade plasmid bioproduction
High-quality plasmid manufacturing for clinical applications, including use as raw materials in cell and gene therapy programmes involving therapeutic mRNA, AAVs, lentiviruses, CAR-T cells, retroviruses and more.
- Full traceability and project-specific documentation
- Creation of a bacterial cell bank for each plasmid
- Storage of the bacterial bank in a secure area
- Production of only one plasmid per High Quality-grade manufacturing campaign in a dedicated room
- Large-scale antibiotic-free culture
- An animal-free production process
- Additional steps to ensure maximum product purity, in line with quality standards compatible with raw materials intended for GMP manufacturing
- Quality controls tailored to the sponsor’s specifications and applicable regulations: percentage of supercoiled DNA, bacterial DNA, residual host-cell proteins, bacterial RNA and endotoxins (list of quality controls)
- Optional plasmid linearisation for mRNA preparation by in vitro transcription
GMP grade plasmid bioproduction
With its GMP manufacturing facility, RD-Biotech can supply GMP grade plasmids as starting materials for innovative therapeutic applications, including cell therapy, gene therapy, and messenger RNA-based therapies and vaccines.
Plasmid bioproduction : which grade is right for my application?
Process development
RD-Biotech puts its bacterial fermentation expertise to work in developing your bioprocesses. Our teams develop and optimise robust, scalable and reproducible culture processes that incorporate all critical production parameters.
From laboratory evaluation to industrial scale-up, we support the development of processes designed to meet the requirements of the most advanced biopharmaceutical applications, particularly gene therapies and innovative vaccines.
By combining scientific expertise, process control and rigorous quality standards, RD-Biotech provides high-performance bioproduction solutions tailored to today’s industrial challenges.
Our strengths
- Optimisation of fermentation conditions
- High-performance purification
- A flexible, bespoke approach tailored to your specifications
- End-to-end support: protocol drafting, technology transfer and regulatory support
