Services
- Molecular biology
  - Plasmid construction and cloning >
    For the production of antibodies and recombinant proteins—mRNA via in vitro transcription—viral vectors, and gene therapy...
    
    Plasmid bioproduction >
    R&D grade - HQ grade - GMP grade
    
    Molecular biology engineering services >
    mRNA bioproduction via IVT – Monoclonal antibody sequencing – Genomic DNA and RNA extraction – Cell line validation – Custom engineering
    
    Analytical Services >
    Stability studies - Sequencing - Capillary Gel Electrophoresis (CGE) - Genotyping
- Antibodies
  - Production of antibodies from hybridomas >
    In vitro hybridoma production – Sequencing – Storage
    
    Recombinant antibody production >
    Antibody formats – Production – Reformatting
    
    Antibody characterization and modification >
    Antibody Characterization – Polishing & Conjugation
- Recombinant protein
  - Multi-system approach >
    Expression of your protein in *Escherichia coli* – in CHO/HEK cells – in yeast – in a cell-free system
    
    Bioproduction >
    In silico feasibility study & System selection – Construction & Optimization of the expression plasmid – Pilot study – Small-scale production – Large-scale production & Scaling-up
    
    Process Development & Scale-up >
    
    Expression Optimization – Process Development – Scale-up & Production – Advanced Characterization & Stability
- Cellular engineering
  - Cell line development >
    Cell line generation – Producer cell lines & Presenting cell lines
    
    Cell production >
    "Ready-to-use" catalog cells – Contract manufacturing – Cell banks
    
    Analytical Services >
    Analytical Testing & Cell Line Validation
- Analytical services
  - Analytical Services > Plasmids
    Stability Study – Sequencing – Capillary Gel Electrophoresis (CGE) – PCR Genotyping – Quality Control
    
    Analytical Services > Antibodies
    
    Characterization – Polishing – Antibody conjugation
    
    Analytical Services > Proteins
    Advanced Characterization & Stability
    
    Analytical Services > Cells
    
    Analytical tests
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RD-Biotech

Technopole TEMIS Santé
18 rue Françoise Dolto
25000 Besançon – France
Tel. +33(0)3 81 53 88 37

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